Coronavirus (COVID-19) products

Coronavirus (COVID-19) research, products and information

Coronavirus (COVID-19) Background

Novel Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The name coronavirus refers to its halo-like appearance; visually similar to a 'solar corona' around the virus particles when viewed under a microscope.

Cellular entry of COVID-19

Image on the left adapted from the Journal of Virology paper by Heurich et al.

PMID: 24227843

Click image to enlarge

 

Catalog number Product name Domain Immunogen Note
28901-1-AP SARS-COV-2 Spike protein (428-506aa) Polyclonal Antibody 428-506aa Ag30684 SARS-COV-2 S protein specific
28869-1-AP SARS-COV-2 Spike protein (126-264aa) Polyclonal Antibody 126-264aa Ag30685 SARS-COV-2 S protein specific
28867-1-AP SARS-COV-2 Spike protein (944-1214aa) Polyclonal Antibody 944-1214aa Ag30679 For SARS/SARS-COV-2/MERS
67758-1-Ig SARS-COV-2 Spike Glycoprotein (319-541 aa) 319-541aa Ag30688 WB, Neutralization, ELISA
28769-1-AP SARS-COV-2 Nucleocapsid Phosphoprotein Polyclonal Antibody 1-419aa Ag30676 WB, ELISA
28882-1-AP SARS-COV-2 Membrane Protein Glycoprotein Polyclonal Antibody 100-222aa Ag30691 ELISA
28904-1-AP SARS-COV-2 Envelope Protein Polyclonal Antibody 1-75aa Ag30690 ELISA
67666-1-Ig SARS-COV-2 Nucleocapsid Phosphoprotein Monoclonal Antibody 1-419aa Ag30676 WB, ELISA
67666-2-Ig SARS-COV-2 Nucleocapsid Phosphoprotein Monoclonal Antibody 1-419aa Ag30676 WB, ELISA
80026-1-RR SARS-COV-2 Nucleocapsid Phosphoprotein Recombinant Antibody 1-419aa Ag30676  *NEW*
80027-1-RR SARS-COV-2 Nucleocapsid Phosphoprotein Recombinant Antibody 1-419aa Ag30676  *NEW*
29287-1-AP SARS-COV-2 NSP1 Polyclonal antibody 1-180aa Ag30935 ELISA
29286-1-AP SARS-COV-2 NSP5 Polyclonal antibody 1-306aa Ag30934 ELISA
29263-1-AP SARS-COV-2 NSP7 Polyclonal antibody 1-83aa Ag30933 ELISA
29262-1-AP SARS-COV-2 NSP8 Polyclonal antibody 1-198aa Ag30932 ELISA
29264-1-AP SARS-COV-2 NSP12 Polyclonal antibody 1-200aa Ag30931 ELISA
29467-1-AP SARS-COV-2 NSP13 Polyclonal antibody 318-469aa Ag30930 ELISA
29301-1-AP SARS-COV-2 NSP15 Polyclonal antibody 1-346aa Ag30929 ELISA

 

Catalog number Product name Applications Species reactivity Publications
66670-1-Ig Human IRF3 Monoclonal Antibody IHC, WB,  Human  
11312-1-AP Human IRF3 Polyclonal Antibody FC, IF, IHC, IP, WB,  Human, Mouse, Rat 56
22392-1-AP Human IRF7 Polyclonal Antibody IHC, IP, WB,  Human 5
66660-1-Ig Human MYD88 Monoclonal Antibody  WB Human, Rat, Mouse 4
23230-1-AP Human MYD88 Polyclonal Antibody  WB Human 55
66992-1-Ig Human NFKB1 Monoclonal Antibody IF, WB,  Human  
14220-1-AP Human NF-κB Polyclonal Antibody IF, IP, WB,  Human, Rat 99
15506-1-AP Human NFKB1,p105,p50-Specific Polyclonal Antibody  WB Human 4
23576-1-AP Human NFKB1 Polyclonal Antibody IF, IHC, WB,  Human 2
15503-1-AP Human NFKB2,p52,p100-Specific Polyclonal Antibody IHC, WB, Human, Mouse 1
66920-1-Ig Human NFKB2 Monoclonal Antibody WB Human  
51085-1-AP Human NFKB2 Polyclonal Antibody WB Human, Mouse  
10409-2-AP Human NFKB2 Polyclonal Antibody IF, IHC, IP, WB, Human, Mouse, Rat 11
CL594-66535 CL594-human NF-κB p65 Monoclonal Antibody IF Human, Rat  
CL488-66535 CL488-human NF-κB p65 Monoclonal Antibody IF Human, Rat  
10745-1-AP Human NF-κB p65 Polyclonal Antibody FC, IF, IHC, IP, WB,  Human, Mouse, Rat, Pig 507
66535-1-Ig Human NF-κB p65 Monoclonal Antibody IF, IHC, WB,   17
66545-1-Ig Human STAT1 Monoclonal Antibody IHC, WB,   4
10144-2-AP Human STAT1 Polyclonal Antibody FC, IF, IHC, IP, WB,   43
66485-1-Ig Human STAT2 Monoclonal Antibody WB    
51075-2-AP Human STAT2 Polyclonal Antibody IHC, WB,    1
16674-1-AP Human STAT2 Polyclonal Antibody IHC, IP, WB, Human 6
66498-1-Ig Human TRAF6 Monoclonal Antibody IF, IHC, WB, Human, Mouse 21
14167-1-AP Human IRF9 Polyclonal Antibody IF, IHC, IP, WB, Human, Mouse, Rat 10
23288-1-AP Human TRIF/TICAM1 Polyclonal Antibody IHC, WB, Human 4
19851-1-AP Human TMEM173/STING Polyclonal Antibody FC, IF, IHC, IP, WB,  Human, Mouse, Rat 46
CL488-19851 CL488-Human TMEM173 Polyclonal Antibody  IF Human  
66680-1-Ig Human TMEM173/STING Monoclonal Antibody IHC, WB,  Human, Rat   
66710-1-Ig Human NOD2 Monoclonal Antibody  WB Human 2
19771-1-AP Human NLRP3 Polyclonal Antibody  WB Human 83
66902-1-Ig Human AIM2 Monoclonal Antibody  WB Human, Mouse, Rat  
11355-1-AP Human LGP2 PolyclonalAantibody IHC, IP, WB,  Human, Mouse, Rat 8
26416-1-AP Human C6orf150 Polyclonal Antibody  IF, WB Human 9
25068-1-AP Human DDX58 Polyclonal Antibody IHC, IP, WB,  Human 1
20566-1-AP Human DDX58 Polyclonal Antibody IF, IP, WB,  Human, Mouse 13
CL488-21775 CL488-human IFIH1 Polyclonal Antibody IF Human, Mouse  
21775-1-AP Human IFIH1/MDA5 Polyclonal Antibody IHC, IP, WB,  Human 16
66770-1-Ig Human IFIH1/MDA5 Monoclonal Antibody IHC, WB,  Human  1
19816-1-AP Human TLR1 Polyclonal Antibody IHC Human, Mouse, Rat  
66645-1-Ig Human TLR2 Monoclonal Antibody WB Human
17766-1-AP Human TLR3 Polyclonal Antibody FC, IHC,  Human 5
66350-1-Ig Human TLR4 Monoclonal Antibody IHC, WB,  Human, Mouse, Rat, Pig 16
19811-1-AP Human TLR4 Polyclonal Antibody IHC, WB,  Human, Mouse, Rat 175
66570-1-Ig Human TLR5 Monoclonal Antibody WB Human, Pig, Mouse, Rat  
19810-1-AP Human TLR5 Polyclonal Antibody IHC, IP, Human, Mouse 4
22240-1-AP Human TLR6 Polyclonal Antibody WB Human, Mouse 3
17232-1-AP Human TLR7 Polyclonal Antibody IHC, WB,  Human, Mouse, Rat 4
67317-1-Ig Human TLR8 Monoclonal Antibody IHC, WB,  Human   

 

SARS-CoV-2 viral entry and impairment of sense of smell - Research published in ACS Chemical Neuroscience by Bilinska et al.

Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age (PMID: 32379417)

Summary provided by Rafal Butowt, PhD, Department of Molecular Cell Genetics, L. Rydygier Collegium Medicum, Nicolaus Copernicus University (Poland), corresponding author.

In the current coronavirus pandemic, a relatively large number of patients have a total loss (anosmia) or deficit of smell (hyposmia), but the mechanism is unknown. Using a mouse model, we showed that cells in the olfactory epithelium lying within the nasal cavity express host receptors that enable the SARS-CoV-2 virus to enter and infect selected cells. We identified these cells as sustentacular cells which are located near olfactory receptor neuronal dendrites containing odorant receptors. These cells are metabolically coupled with olfactory receptor neurons, participating in detoxification, odorant-desensitization and as an energy supplier to the olfactory neurons. Thus, SARS-CoV-2 infection of sustentacular cells could explain the olfactory deficient phenotype in COVID-19 patients. We also show that some proteins important for SARS-CoV-2 entry are at higher levels in older mice olfactory epithelium than in younger mice. It is speculated that sustentacular cells in the olfactory epithelium may contain more SARS-CoV-2 viral particle than cells in the oral cavity, making it easier to detect people that are infected with the virus.

Butowt and colleagues used Proteintech’s ACE2 antibody (21115-1-AP) to detect expression of the target in olfactory tissue throughout the study. Proteintech’s HSP25 antibody (18284-1-AP) was used to mark sustentacular cells of the olfactory epithelium.

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

Pathogenesis of SARS-CoV-2 in human respiratory tract and conjunctiva. Research published in The Lancet Respiratory Medicine featuring Proteintech’s CC10/Uteroglobin (10490-1-AP).

Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of 2 broad antiviral therapy 

MTHFD1 Antibody (10794-1-AP) - Anderson et al.

No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes

TMPRSS2 Antibody (14437-1-AP) – Baratchian et al.

LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic 4 SARS-CoV-2

LY6E Antibody (22144-1-AP) - Zhao et al

Supply Chain Notice

Proteintech is committed to ensuring your research continues during the COVID-19 situation. We understand much of your research is extremely important to the health of the community. As an original manufacturer for its entire catalog of antibodies and proteins, we are here to support you.

Proteintech has five sites globally with full stock inventory available for next day delivery. For this reason, we do not anticipate any issues with our supply chain and orders received will continue to be processed as normal until further notice.

Moreover, we hope you and your family, friends and colleagues remain safe and well. We will keep a close monitoring of the situation and will update our efforts accordingly.

If you have any questions or concerns, please   contact us.