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  • KD/KO Validated

TMEM173/STING Monoclonal antibody

TMEM173/STING Monoclonal Antibody for IHC, WB, ELISA

Host / Isotype

Mouse / IgG2b


Human, Rat and More (2)







Cat no : 66680-1-Ig


FLJ38577, hMITA, hSTING, Mediator of IRF3 activation, MITA, MPYS, NET23, STING, TMEM173, TMEM173/STING, transmembrane protein 173

Tested Applications

Positive WB detected inHSC-T6 cells, THP-1 cells, HEK-293 cells, HepG2 cells, Jurkat cells
Positive IHC detected inhuman tonsillitis tissue, human spleen tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Planning an IHC experiment? We recommend our IHCeasy STING Ready-To-Use IHC Kit. STING primary antibody included.

Recommended dilution

Western Blot (WB)WB : 1:2000-1:10000
Immunohistochemistry (IHC)IHC : 1:500-1:2000
Sample-dependent, check data in validation data gallery

Product Information

66680-1-Ig targets TMEM173/STING in WB, IHC, IF applications and shows reactivity with Human, Rat samples.

Tested Reactivity Human, Rat
Cited Reactivityhuman, mouse
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen TMEM173/STING fusion protein Ag20363
Full Name transmembrane protein 173
Calculated molecular weight 379 aa, 42 kDa
Observed molecular weight 37 kDa
GenBank accession numberBC047779
Gene symbol TMEM173
Gene ID (NCBI) 340061
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Stimulator of interferon genes (STING, also known as ERIS, MITA and MPYS, and encoded by TMEM173) is a transmembrane adaptor protein that facilitates innate immune signalling (PMID: 18724357). STING is widely expressed in various cell types such as endothelial cell, epithelial cells, T cells, macrophages and dendritic cells (PMID: 26603901). It is predominantly located in endoplasmic reticulum (ER). STING functions as a sensor of cytosolic DNA and promotes the production of type I interferons and and pro-inflammatory cytokines. STING is a 379 amino acid protein with a calculated molecular wight of 42 kDa. It has been observed at 35-40 kDa (PMID: 27324217; 29632140; 30918080), and 70-80 kDa corresponding to the expected size of a STING dimer (PMID: 25790474; 29491158).


Product Specific Protocols
WB protocol for TMEM173/STING antibody 66680-1-IgDownload protocol
IHC protocol for TMEM173/STING antibody 66680-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols




Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.

Authors - Yang Zhou

Cell Immunol

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer.

Authors - Jiaqi Shi


Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.

Authors - Kunpeng Liu
  • KO Validated

Cell Death Differ

The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.

Authors - Miao Zhao
  • KO Validated
humanWB, IF


Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING.

Authors - Run Fang


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Will (Verified Customer) (04-25-2019)

good antibody, will order again

  • Applications: Western Blot,