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TMEM173/STING Monoclonal antibody
TMEM173/STING Monoclonal Antibody for IHC, WB, ELISA
Cat no : 66680-1-Ig
Validation Data Gallery
|Positive WB detected in||HeLa cells, HepG2 cells, HSC-T6 cells, HEK-293 cells, THP-1 cells, MOLT-4 cells, Jurkat cells|
|Positive IHC detected in||human tonsillitis tissue, human spleen tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:5000-1:50000|
|Immunohistochemistry (IHC)||IHC : 1:500-1:2000|
|Sample-dependent, check data in validation data gallery|
66680-1-Ig targets TMEM173/STING in WB, IP, IHC, IF, ELISA applications and shows reactivity with Human, Rat samples.
|Tested Reactivity||Human, Rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||TMEM173/STING fusion protein Ag20363|
|Full Name||transmembrane protein 173|
|Calculated molecular weight||379 aa, 42 kDa|
|Observed molecular weight||37 kDa|
|GenBank accession number||BC047779|
|Gene ID (NCBI)||340061|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Stimulator of interferon genes (STING, also known as ERIS, MITA and MPYS, and encoded by TMEM173) is a transmembrane adaptor protein that facilitates innate immune signaling (PMID: 18724357). STING is widely expressed in various cell types such as endothelial cells, epithelial cells, T cells, macrophages, and dendritic cells (PMID: 26603901). It is predominantly located in the endoplasmic reticulum (ER). STING functions as a sensor of cytosolic DNA and promotes the production of type I interferons and pro-inflammatory cytokines. STING is a 379 amino acid protein with a calculated molecular weight of 42 kDa. It has been observed at 35-40 kDa (PMID: 27324217; 29632140; 30918080), and 70-80 kDa corresponding to the expected size of a STING dimer (PMID: 25790474; 29491158).
Oxid Med Cell Longev
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer.
Cancer Cell Int
AMICA1 is a diagnostic and prognostic biomarker and induces immune cells infiltration by activating cGAS-STING signaling in lung adenocarcinoma.
Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.
J Innate Immun
Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Will (Verified Customer) (04-25-2019)
good antibody, will order again