Validation Data Gallery
|Positive WB detected in||human placenta tissue, fetal human brain tissue, human plasma, 37°C incubated human placenta tissue, pig brain tissue, HeLa cells, rabbit heart tissue, MDA-MB-231 cells, A549 cells, pig heart tissue|
|Positive IF detected in||SH-SY5Y cells, human embronic stem cells|
|Positive FC detected in||SH-SY5Y cells|
|Western Blot (WB)||WB : 1:1000-1:6000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
60067-1-Ig targets Neuropilin 1 in WB, IP, IF, FC, CoIP, ELISA applications and shows reactivity with human, pig, rabbit samples.
|Tested Reactivity||human, pig, rabbit|
|Cited Reactivity||human, mouse, Xenopus|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Neuropilin 1 fusion protein Ag0931|
|Full Name||neuropilin 1|
|Calculated molecular weight||103 kDa|
|Observed molecular weight||130 kDa|
|GenBank accession number||BC007737|
|Gene ID (NCBI)||8829|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Neuropilin-1 (NRP1) is a 130-140 kDa transmembrane glycoprotein expressed by endothelial, dendritic, and regulatory T cells, as well as several other normal cell types and malignant tumor cells. NRP1 was first identified as a semaphorin (SEMA) receptor, involved in axonal guidance in embryonic development. NRP1 was also shown to act as a receptor for vascular endothelial growth factor (VEGF) and a promoter of angiogenesis through its interaction with VEGF-A165 (and other VEGFs) and the receptor tyrosine kinase (RTK) VEGF-R2. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.
Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.
Semaphorin-3A, Neuropilin-1 and Plexin-A1 in Prosthetic-Particle Induced Bone Loss.
Perivascular Neuropilin-1 expression is an independent marker of improved survival in renal cell carcinoma.
Am J Cancer Res
CMTM6 promotes cell proliferation and invasion in oral squamous cell carcinoma by interacting with NRP1.
Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy.
Exp Eye Res
Expression of axon guidance ligands and their receptors in the cornea and trigeminal ganglia and their recovery after corneal epithelium injury.