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  • KD/KO Validated

IFITM3 Polyclonal antibody

IFITM3 Polyclonal Antibody for FC, IF, IP, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat and More (4)


WB, IP, IHC, IF, FC, CoIP, Blocking assay, ELISA



Cat no : 11714-1-AP


1 8U, Fragilis, IFITM3, IP15

Tested Applications

Positive WB detected inHeLa cells, mouse colon tissue, HepG2 cells, LNCaP cells, THP-1 cells
Positive IP detected inHeLa cells
Positive IF detected inHeLa cells
Positive FC detected inHeLa cells
Planning an IF experiment? We recommend our CoraLite®488 and CoraLite®594 conjugated versions of this antibody.

Recommended dilution

Western Blot (WB)WB : 1:5000-1:50000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
Immunofluorescence (IF)IF : 1:400-1:1600
Sample-dependent, check data in validation data gallery

Product Information

11714-1-AP targets IFITM3 in WB, IP, IHC, IF, FC, CoIP, Blocking assay, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat, African green monkey, chicken, goat, pig
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IFITM3 fusion protein Ag2285
Full Name interferon induced transmembrane protein 3 (1-8U)
Calculated molecular weight 133 aa, 15 kDa
Observed molecular weight 14 kDa
GenBank accession numberBC006794
Gene symbol IFITM3
Gene ID (NCBI) 10410
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

IFITM3, also named as interferon-inducible protein 1-8U, belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. IFITM3, the most potent antiviral IFITM, was found to inhibit an uncharacterized early infectious event after VSV endocytosis, but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. Catalog#11714-1-AP is a rabbit polyclonal antibody raised against the full-length of human IFITM3.


Product Specific Protocols
WB protocol for IFITM3 antibody 11714-1-APDownload protocol
IF protocol for IFITM3 antibody 11714-1-APDownload protocol
IP protocol for IFITM3 antibody 11714-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Chem Biol

IFITM3 directly engages and shuttles incoming virus particles to lysosomes.

Authors - Jennifer S Spence
  • KO Validated

Int J Biol Macromol

Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro.

Authors - Shouwen Du


Vpr Enhances HIV-1 Env Processing and Virion Infectivity in Macrophages by Modulating TET2-Dependent IFITM3 Expression.

Authors - Qi Wang
  • KD Validated

Cell Rep

Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells.

Authors - Ayesha Ali

Cell Chem Biol

Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.

Authors - Xiaojun Wu
  • KO Validated


Opposing activities of IFITM proteins in SARS-CoV-2 infection.

Authors - Guoli Shi


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Thomas (Verified Customer) (06-29-2022)

Works fine in WB and IF

  • Applications: Western Blot, Immunofluorescence

Xiuqing (Verified Customer) (03-21-2022)

worked very well for western blot

  • Applications: Western Blot
  • Cell Tissue Type: MARC-145 cells, H1299 cells