|Positive WB detected in||Y79 cells, HeLa cells|
|Western Blot (WB)||WB : 1:500-1:3000|
|Sample-dependent, check data in validation data gallery|
The immunogen of 20489-1-AP is DAXX Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||DAXX fusion protein Ag14519|
|Full Name||death-domain associated protein|
|Calculated molecular weight||740 aa, 81 kDa|
|Observed molecular weight||120 kDa, 70 kDa|
|GenBank accession number||BC109074|
|Gene ID (NCBI)||1616|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Death associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. It has been shown to translocate from the nucleus to the cytoplasm under conditions of stress and to activate the Jun N-terminal kinase (JNK) pathway. Somatic mutations of death associated protein (DAXX) have been found in ALT cancers, including pancreatic neuroendocrine (panNET) cancers and glioblastoma multiforme (GBM) cancers.
Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen.
J Biol Chem
The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Alexandros (Verified Customer) (03-03-2023)
Very happy with the final image we have in our blots compared to other antibodies we have previously used