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IFITM2 Polyclonal antibody

IFITM2 Polyclonal Antibody for WB, IP, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 12769-1-AP


1 8D, IFITM2

Tested Applications

Positive WB detected inHepG2 cells, MCF-7 cells
Positive IP detected inHepG2 cells
Positive IHC detected inhuman breast cancer tissue, mouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:4000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)IF : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12769-1-AP targets IFITM2 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, pig
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IFITM2 fusion protein Ag3451
Full Name interferon induced transmembrane protein 2 (1-8D)
Calculated Molecular Weight 132 aa, 15 kDa
Observed Molecular Weight 15 kDa
GenBank Accession NumberBC009696
Gene Symbol IFITM2
Gene ID (NCBI) 10581
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus , by inhibiting the early steps of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also they serve as important components of the innate immune system to restrict HIV-1 infection. Catalog#12769-1-AP is a rabbit polyclonal antibody produced with full-length of human IFITM2.


Product Specific Protocols
WB protocol for IFITM2 antibody 12769-1-APDownload protocol
IHC protocol for IFITM2 antibody 12769-1-APDownload protocol
IF protocol for IFITM2 antibody 12769-1-APDownload protocol
IP protocol for IFITM2 antibody 12769-1-APDownload protocol
FC protocol for IFITM2 antibody 12769-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

Authors - Abraham L Brass

Cell Stem Cell

PMID: 30416070

Authors - Carolina Petrillo

Cell Host Microbe

Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.

Authors - Toshana L Foster
  • KD Validated
humanWB, FC

Cell Host Microbe

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread.

Authors - Alex A Compton
  • KD Validated

Nat Commun

IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses

Authors - M. Clement

Nat Commun

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

Authors - Alessandra Rosati
  • KD Validated