Breast Cancer

Breast Cancer Research focus

Breast Cancer Research focus

Introduction

Breast cancer is the largest leading cause of death in women. It is not the primary breast tumor, but the metastases that are responsible for the high incidences of death. Although medical advances have been able to decrease the mortality rate, more and more women are developing breast cancer each year. (1)

HER2/ErbB2: Breast cancer diagnosis

HER2/ErbB2 (human epidermal growth factor) is a protein that can affect the growth of several cancer cells, and its overexpression has been  reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer (2) (3).

IHC staining of paraffin-embedded human breast cancer using HER2/ErbB2 antibody (51105-1-AP) at a dilution of 1:50 (40x objective).

Related Antibodies

Antibody Name Cat No Type
HER2/ErbB2 18299-1-AP Rabbit Poly
HER2/ErbB2 51105-1-AP Mouse Mono

PAX8: Promoting breast cancer proliferation

PAX8 is a member of the paired box (PAX) family, and is involved in oncogenesis. Several recent studies have shown that PAX8 facilitates important regulatory roles in breast cancer cell proliferation and tumor progression. (4) (5).

Related Antibodies

Antibody Name Cat No Type
PAX8 10336-1-AP Rabbit Poly
PAX8 60145-4-IG Mouse Mono
PAX8-Specific 66073-1-IG Mouse Mono
Pan-PAX 21383-1-AP Rabbit Poly

ESR/ER

The estrogen receptor (ESR/ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Expression and mutation of ESR/ER are common features in breast cancer. (6) (7).

IHC staining of paraffin-embedded human breast cancer using ER antibody (21244-1-AP) at a dilution of 1.25 (40x objective). Heat mediated antigen retrieved with citric acid buffer, pH6.0.

Related Antibodies

Antibody Name Cat No Type
ESR/ER 21244-1-AP Rabbit Poly

More Breast cancer-related antibodies from Proteintech

Antibody Name Cat No Type
ADAM12 14139-1-AP Rabbit Poly
COL1A2 14695-1-AP Rabbit Poly
FKBPL 10060-1-AP Rabbit Poly
MMP-1 10371-2-AP Rabbit Poly
PALLD 10853-1-AP Rabbit Poly
PR 25871-1-AP Rabbit Poly
PR 66300-1-IG Mouse Mono

References

(1) Eifel P, et al. J. Natl Cancer Inst, 2001; 93: 979–989.

(2) Flavia F, et al. BMC Cancer, 2013; 19: 13: 81.

(3) Lu Y, et al. Oncotarget, 2016; Mar 16.

(4) Zhong X, et al. BMP Rep, 2011; 44: 595–600.

(5) Xia X, et al. Onc Letters, 2015; 29: 1501–06.

(6) Nadji M, et al. Am J Clin Path, 2005; 123: 21–7.

(7) Rhodes A, et al. J Clin Pathol, 2000; 53: 688–96.

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Posted:
1 March, 2017

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