JNK Pathway: Pathway Poster Library

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All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.

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JNK Signaling

JNKs (c-Jun N-terminal kinases), also known as stress-activated protein kinases, are a subfamily of mitogen-activated protein (MAP) kinases. They are strongly stimulated by numerous environmental stresses but also by mitogens, inflammatory cytokines, oncogenes, and inducers of cell differentiation or morphogenesis (1).

Three major genes have been identified as regulators of the JNK pathway. JNK1 and JNK2 have broad tissue distribution and play a significant role in insulin resistance, inflammation, and cell signaling. JNK3 is predominantly found in the central nervous system (CNS) neurons. The JNKs are activated by phosphorylation on threonine and tyrosine residues via MKK4 and MKK7; inactivation of the JNKs is induced by MAPK phosphatases, which usually function in a negative feedback loop (2).

Since deregulation of JNK is linked with various diseases, including neurodegenerative disorders (Parkinson’s, Alzheimer’s), diabetes, cancer, cardiac hypertrophy, and asthma, JNK inhibitors, activators, and isoforms have a potential as therapeutic targets. (3)

Download the JNK Pathway poster here

Related Antibodies

ASK1	HSP70	MEK4	PI3K P55(Gamma)
ATF2-Specific	IRS1	MEKK3	Rac1
CDC42	JIP1	MKK7	RRAS
CRK	JNK	MKP-2	SOS1
DLK1	JNK2	MLK3	TAK1
ELK1	MAPK10	NFATC3	TAU
ERK1/2	MEK1-Specific	P53	TRADD
GRB2	MEK2	pan Ras	TRAF6

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AKT Signaling Alzheimer's Disease AML Signaling Apoptosis Pathway BRCA Pathway Caspase Cascade Pathway ER Stress Pathway GPCR Pathway GSK3 Signaling Hedgehog Signaling IL-6 Pathway Insulin Pathway JAK/STAT Signaling JNK Signaling mTOR Signaling Neurotrophin Pathway NFKB Pathway NOTCH Signaling P53 Signaling RAS Receptor Pathway TGF-beta Pathway Toll-like Receptor Pathway VEGF Signaling Wnt Signaling AMPK Pathway ATM Pathway BDNF Pathway eNOS Pathway EGF Pathway MAPK Pathway P38-MAPK Pathway

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1. c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.
2. The role of scaffold proteins in JNK signalling.
3. JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases.