Alzheimer's Disease Signaling Pathway

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Alzheimer's Disease Overview

Nowadays Alzheimer's disease (AD) alone accounts for between and 60 and 70% of all dementia cases. AD is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs), where amyloid beta is a major component of these plaques. From a genetic perspective, four genes are deeply involved in AD: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin2 (PS2), and apolipoprotein E (ApoE). Mutations in APP and PS proteins provoke an increase of amyloid-beta peptides, mostly the amyloidogenic form – amyloid-beta 42. The correlation between APOE and AD is significant; however, APOE genotyping is neither fully specific nor sensitive.

Popular Alzheimer's Disease Antibodies

AP repeat	Cytochrome C	MME,CD10
APH1A	ERK1/2/MAPK1	p35
APP	FADD	PSEN1
APP-BP1	FAS/CD95	SNCA
BACE1	Fe65/APBB1	Tau
BAD	GAPDH	TDP-43
BID	GNAQ	TLR4
Calpain	GSK3 beta	TNF-alpha
CASP8	LPL	Vimentin

TAU

 TDP-43

 

Ihc of paraffin-embedded human brain tissue slide using 10274-1-AP( TAU Antibody) at dilution of 1:200 (under 40x lens)

 IHC of paraffin-embedded human brain using 10782-2-AP(TARDBP antibody) at dilution of 1:50 (under 40x lens)

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