Alzheimer's Disease Signaling Pathway

Download or request a pathway poster for your lab

All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.


Alzheimer's Disease Overview

Nowadays Alzheimer's disease (AD) alone accounts for between and 60 and 70% of all dementia cases. AD is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs), where amyloid beta is a major component of these plaques. From a genetic perspective, four genes are deeply involved in AD: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin2 (PS2), and apolipoprotein E (ApoE). Mutations in APP and PS proteins provoke an increase of amyloid-beta peptides, mostly the amyloidogenic form – amyloid-beta 42. The correlation between APOE and AD is significant; however, APOE genotyping is neither fully specific nor sensitive.

Download: Alzheimer's disease signaling pathway poster

Popular Alzheimer's Disease Antibodies

AP repeat Cytochrome C MME,CD10
APH1A ERK1/2/MAPK1 p35
APP FADD PSEN1
APP-BP1 FAS/CD95 SNCA
BACE1 Fe65/APBB1 Tau
BAD GAPDH TDP-43
BID GNAQ TLR4
Calpain GSK3 beta TNF-alpha
CASP8 LPL Vimentin
TAU  TDP-43

 

Ihc of paraffin-embedded human brain tissue slide using 10274-1-AP( TAU Antibody) at dilution of 1:200 (under 40x lens)  IHC of paraffin-embedded human brain using 10782-2-AP(TARDBP antibody) at dilution of 1:50 (under 40x lens)

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Posted:
3 August, 2017

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