Validation Data Gallery
Technical Specifications
| GeneID | 7040 |
| Species | Human |
| Expression | HEK293 |
| Activity(Primary) | Typically ≤ 0.5 ng/mL |
| Specific Activity | minimally 1.00 x 107 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | P01137 |
| Molecular Mass | 13 kDa reduced, 25 kDa non-reduced, homodimer, non-glycosylated |
| Formulation | 50 mM NaOAc pH 3.7, See Certificate of Analysis for details |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, and cell differentiation. TGF acts synergistically with TGFA in inducing transformation process. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB having specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling being a potent stimulator of an osteoblastic bone formation (PMID: 11586292).
Synonyms
CED, DPD1, LAP, TGF B1, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgf-beta1
Publications
| Species | Title |
|---|---|
Nature Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. | |
Nat Biotechnol Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. | |
Immunity Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis | |
Cell Metab Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK | |
Nat Cell Biol A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1. | |
ACS Nano Deep-Learning-Based Nanomechanical Vibration for Rapid and Label-Free Assay of Epithelial Mesenchymal Transition |
Reviews
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
FH MARIA (Verified Customer) (11-13-2024) | We applied TGFb to the stem cell culture, together with other reagents. It worked fine, we didnt have any problem
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FH Linshan (Verified Customer) (05-23-2024) | This product has an effect in my experiment. I would recommend it.
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FH Sebastian (Verified Customer) (10-25-2023) | Used to stimulate cardiac fibroblasts. Worked well.
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