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HDAC1 Antibody

KD/KO Validated

Antibody Catalog number Type Applications
HDAC1 10197-1-AP Rabbit Poly ELISA, FC, IF, IHC, IP, WB

Histone deacetylases (HDACs) are a class of enzymes that remove the acetyl groups from the lysine residues in histones. This modification condenses and transcriptionally silences regions of chromatin. Due to their influence on gene expression, HDACs play a crucial role in development and physiology, having many implications for disease and therapy.

As an example, placental multidrug resistanceassociated protein 2 (MRP2), an HDAC, plays a significant role in regulating drugs' transplacental transfer rates. While working with Proteintech HDAC1 antibody (10197-1-AP), Duan and colleagues showed that HDACs inhibition can up-regulate placental MRP2 expression.1

IHC staining of paraffin-embedded human testis using HDAC1 antibody (10197-1-AP) at a dilution of 1:50 (under 40x lens)
Immunohistochemical staining of paraffin-embedded human testis using HDAC1 antibody (10197-1-AP) at a dilution of 1:50 (under 40x lens).
1X10^6 HeLa cells were stained with the 0.2ug HDAC1 antibody (10197-1-AP, red) and a control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) at a dilution of 1:1000
1X10^6 HeLa cells were stained with the 0.2ug HDAC1 antibody (10197-1-AP, red) and a control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) at a dilution of 1:1000.

 

Related Products

Antibody Catalog number Type Applications
HDAC1 66085-1-Ig Mouse Mono ELISA, IF, IHC, WB
HDAC2 - KD/KO Validated 12922-3-AP Rabbit Poly ELISA, FC, IF, IHC, IP, WB
HDAC3 - KD/KO Validated 10255-1-AP Rabbit Poly ELISA, IHC, IP, WB 
HDAC4 -KD/KO Validated 17449-1-AP Rabbit Poly  ELISA, chIP, IF, IHC, IP, WB
HDAC4-Specific 16165-1-AP Rabbit Poly ELISA, WB, IP, IHC 
HDAC5-Specific   16166-1-AP Rabbit Poly ELISA, WB, IHC, IF
HDAC6   12834-1-AP Rabbit Poly ELISA, IF, IHC, IP, WB 
HDAC7 26207-1-AP Rabbit Poly ELISA, IP 
HDAC8 17548-1-AP Rabbit Poly ELISA, WB, IP, IF 
HDAC10 24913-1-AP Rabbit Poly ELISA, WB, IHC, IF 

 

References

1. Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line (PMID: 28524836).