DGCR8 C-Terminal Antibody
KD/KO Validated
| Antibody | Catalog Number | Type | Applications | |
|
10996-1-AP |
Rabbit Poly |
ELISA, ChIP, FC, IF, IHC, IP, WB |
57 Publications |
MicroRNA cleavage by the Drosha-Dgcr8 ‘Microprocessor’ complex is critical for microRNA biogenesis. DGCR8 is an RNA-binding protein that assists the RNase III enzyme in the processing of microRNAs. However, DGCR8’s other roles in the cell are still under investigation. Using Proteintech DGCR8 C-Terminal antibody (10996-1-AP), scientists can discover more about DGCR8’s functions. Recently, Cirera-Salinas et al., described a new non-canonical function of DGCR8 in the modulation of the alternative splicing of Tcf7l1 mRNA in addition to its established function in microRNA biogenesis.¹
In the context of neurological disorders, individuals lacking DGCR8 function are at increased risk of developing schizophrenia. Eon and colleagues discovered that dysregulation of the Dgcr8-Drd2 underlies some pathogenic mechanisms related to emotional memory deficits for those with DGCR8 deletions.²
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| Immunofluorescent analysis of SH-SY5Y cells, using DGCR8 antibody (10996-1-AP) at a 1:50 dilution and FITC-labeled donkey anti-rabbit IgG (green). Blue pseudocolor = DAPI (fluorescent DNA dye). |
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| IP Result of anti-DGCR8 C-terminal (IP: 10996-1-AP, 3ug; Detection: 10996-1-AP, 1:800) with HEK-293 cells lysate 2700ug. |
Related products
Here's just a small selection of popular antibodies for epigenetics.
Download the full list here |
| Antibody | Catalog number | Type | Applications |
| Drosha | 55001-1-AP | Rabbit Poly | ELISA, WB |
| DICER1 - KD/KO Validated | 20567-1-AP | Rabbit Poly | ELISA, IF, IHC, IP, WB |
| CNOT1 - KD/KO Validated | 14276-1-AP | Rabbit Poly | ELISA, CoIP, IHC, IP, WB |
| HNRNPK | 11426-1-AP | Rabbit Poly | ELISA, FC, IF, IHC, IP, WB |
| TRBP - KD/KO Validated | 15753-1-AP | Rabbit Poly | ELISA, WB, IP, IHC, IF |
| AGO2 | 10686-1-AP | Rabbit Poly | ELISA, IHC, IP, WB |
| EIF2C1-Specific | 19690-1-AP | Rabbit Poly | ELISA, WB, IHC, IF |
| DGCR8 N-Terminal | 25835-1-AP | Rabbit Poly | ELISA, IF, IP, WB |
| DGCR8 | 60084-1-Ig | Mouse mono | ELISA, IP, WB |
| CNOT8 - KD/KO Validated | 10752-1-AP | Rabbit Poly | ELISA, WB, IP, IHC, IF |
References
1. Noncanonical function of DGCR8 controls mESC exit from pluripotency (PMID: 28100686).
2. Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala (PMID: 28538174)
