AIDA regulates intestinal fat absorption & obesity

13 Proteintech antibodies are cited in a recent Cell Metabolism publication.

'AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.' Luo et al., 2018 

Luo et al show that the inhibition of endoplasmic-reticulum-associated degradation (ERAD) increases the abundance of triacylglycerol synthesis enzymes and fat absorption in the small intestine. The AIDA-mediated ERAD system selectively downregulates fat synthesis enzymes. As this mechanism impinges on intestinal fat absorption, it can help prevent obesity.

The cover image is a nod to Giuseppe Verdi’s work Aida, in which the Egyptian princess Aida collaborates with the ERAD system (allegorically depicted as the Egyptian guard Radamès and the cat Bast) to counteract the effects of fat-laden foods, illustrated in hieroglyphics-style on the mural. Cover art by Ye Li.

Cited Proteintech antibodies

Antibody Catalog number  Type  Notes
AIDA 23724-1-AP Rabbit Polyclonal KD/KO Validated
VCP 10736-1-AP Rabbit Polyclonal 3 Publications
SDHA 14865-1-AP Rabbit Polyclonal 13 Publications
HRD1 13473-1-AP Rabbit Polyclonal KD/KO Validated
Calnexin 10427-2-AP Rabbit Polyclonal 29 Publications
Tubulin-Alpha 66031-1-Ig Mouse Monoclonal 73 Publications
FABP2 21252-1-AP Rabbit Polyclonal 2 Publications
APOB 20578-1-AP Rabbit Polyclonal 3 Publications
TIP47 10694-1-AP Rabbit Polyclonal 8 Publications
MOGAT2 19514-1-AP Rabbit Polyclonal 1 Publication
AGPAT9 20603-1-AP Rabbit Polyclonal 1 Publication
ATF4 10835-1-AP Rabbit Polyclonal KD/KO Validated