AIDA regulates intestinal fat absorption & obesity
13 Proteintech antibodies are cited in a recent Cell Metabolism publication.
Luo et al show that the inhibition of endoplasmic-reticulum-associated degradation (ERAD) increases the abundance of triacylglycerol synthesis enzymes and fat absorption in the small intestine. The AIDA-mediated ERAD system selectively downregulates fat synthesis enzymes. As this mechanism impinges on intestinal fat absorption, it can help prevent obesity.
The cover image is a nod to Giuseppe Verdi’s work Aida, in which the Egyptian princess Aida collaborates with the ERAD system (allegorically depicted as the Egyptian guard Radamès and the cat Bast) to counteract the effects of fat-laden foods, illustrated in hieroglyphics-style on the mural. Cover art by Ye Li.
Cited Proteintech antibodies