TDP-43 product focus

Proteintech’s TDP-43 polyclonal antibody played a seminal role in the discovery of this protein


TDP-43 accumulation aggregation in the brain is a hallmark feature of many neurodegeneration diseases including frontotemporal lobar dementia (FTLD), amyotrophic lateral sclerosis (ALS) and alzheimers disease.

Proteintech’s TDP-43 polyclonal antibody 10782-2-AP played a seminal role in the discovery of this protein (Neuman et al. 2006). Our whole protein immunogen strategy enabled the visualisation of aggregated TDP-43 in more disease scenarios.

Proteintech TDP43 products have over 1450 citations to date, and we have developed a wide range of products to target TDP-43 in a variety of states such as the pathogenic c-terminal fragment and phosphorylated TDP-43.

 

TDP43 polyclonal antibody 10782-2-AP
1293 publications  KD/KO validated
TDP43 recombinant antibody dystrophic neurites

40X of FTLD-U case stained by 10782-2-AP (1:3000) showing dystrophic neurites.

 

*New* IHCeasy TDP-43 Ready-to-Use IHC Kit KHC0001

 

TDP43 IHC mouse brain tissue proteintech

Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using KHC0001 (TDP-43 IHC Kit)..

IHCeasy kit by proteintech

*New* Phospo-TDP43 (Ser409/410) recombinant antibody 80007-1-RR  

Non-treated and ethacrnic acid treated HeLa cells were subjected to SDS PAGE followed by western blot with 80007-1-RR (Phospho-TDP43 (Ser409/410) antibody)

Control and ethacrynic acid treated HeLa cells. 80007-1-RR 1:300

 

CoraLite®488-conjugated recombinant TDP-43 antibody for ImmunoFluoresence and Intracellular flow cytometry CL488-80002
Immunofluorescence Intracellular Flow Cytometry

Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using CL488-80002 (TDP-43

4% PFA fixed mouse brain using 1:100 of CL488-80002

mouse splenocytes stained with CD4 and FOXP3 conjugated antibody to coralite 488 for flow cytometry

HeLa cells stained with 0.2 µg CL488-80002. Cells were fixed with Transcription Factor Staining Buffer Kit (PF00011).

List of TDP-43 products

 

Antigen Name
CatalogNo
Host and Clonality
Application

TDP-43

10782-2-AP

Rabbit Polyclonal

FC, IF, IHC, WB, ELISA

TDP-43 (C-terminal)

12892-1-AP

Rabbit Polyclonal

IF, IHC, IP, WB, ELISA

TDP-43

18280-1-AP

Rabbit Polyclonal

FC, IF, IHC, IP, WB, ELISA

Phospho-TDP43 (Ser409/410)

22309-1-AP

Rabbit Polyclonal

WB, ELISA

TDP-43 (human specific)

60019-2-Ig

Mouse Monoclonal

FC, IHC, IP, WB, ELISA

Phospho-TDP43 (Ser403/404)

66079-1-Ig

Mouse Monoclonal

FC, WB, ELISA

Phospho-TDP43 (Ser409/410)

66318-1-Ig

Mouse Monoclonal

WB, ELISA

TDP-43

66734-1-Ig

Mouse Monoclonal

FC, IHC, WB, ELISA

TDP-43 (C-terminal)

67345-1-Ig

Mouse Monoclonal

FC, IF, IHC, WB, ELISA

TDP-43

80001-1-RR

Rabbit Recombinant 

FC, IHC, WB, ELISA

TDP-43 (for IF/FC)

80002-1-RR

Rabbit Recombinant 

FC, IF, ELISA

Phospho-TDP43 (Ser409/410)

80007-1-RR

Rabbit Recombinant 

IHC, WB, ELISA

TDP-43

CL488-10782

Rabbit Polyclonal

FC (Intra), IF

TDP-43 (C-terminal)

CL488-12892

Rabbit Polyclonal

FC (Intra), IF

TDP-43 (C-terminal)

CL488-67345

Mouse Monoclonal

IF

TDP-43 (for IF/FC)

CL488-80002

Rabbit Recombinant 

FC (Intra), IF

TDP-43 (C-terminal)

CL594-12892

Rabbit Polyclonal

FC (Intra), IF

TDP-43 (C-terminal)

CL594-67345

Mouse Monoclonal

IF

TDP-43 (for IF/FC)

CL594-80002

Rabbit Recombinant 

FC (Intra), IF

Human TDP-43 ELISA kit

KE00005

Mix

ELISA (plasma and serum)

Human TDP-43 ELISA kit

KE00009

Mix

ELISA (CSF and cell lysate)

 


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