TDP-43 product focus

Proteintech’s TDP-43 polyclonal antibody played a seminal role in the discovery of this protein

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TDP-43 accumulation aggregation in the brain is a hallmark feature of many neurodegeneration diseases including frontotemporal lobar dementia (FTLD), amyotrophic lateral sclerosis (ALS) and alzheimers disease.

Proteintech’s TDP-43 polyclonal antibody 10782-2-AP played a seminal role in the discovery of this protein (Neuman et al. 2006). Our whole protein immunogen strategy enabled the visualisation of aggregated TDP-43 in more disease scenarios.

Proteintech TDP43 products have over 1450 citations to date, and we have developed a wide range of products to target TDP-43 in a variety of states such as the pathogenic c-terminal fragment and phosphorylated TDP-43.

TDP43 polyclonal antibody 10782-2-AP

1293 publications  KD/KO validated

40X of FTLD-U case stained by 10782-2-AP (1:3000) showing dystrophic neurites.

*New* IHCeasy TDP-43 Ready-to-Use IHC Kit KHC0001

Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using KHC0001 (TDP-43 IHC Kit)..

*New* Phospo-TDP43 (Ser409/410) recombinant antibody 80007-1-RR  

Control and ethacrynic acid treated HeLa cells. 80007-1-RR 1:300

CoraLite®488-conjugated recombinant TDP-43 antibody for ImmunoFluoresence and Intracellular flow cytometry CL488-80002

Immunofluorescence

Intracellular Flow Cytometry

4% PFA fixed mouse brain using 1:100 of CL488-80002

HeLa cells stained with 0.2 µg CL488-80002. Cells were fixed with Transcription Factor Staining Buffer Kit (PF00011).

List of TDP-43 products

Antigen Name	CatalogNo	Host and Clonality	Application
TDP-43	10782-2-AP	Rabbit Polyclonal	FC, IF, IHC, WB, ELISA
TDP-43 (C-terminal)	12892-1-AP	Rabbit Polyclonal	IF, IHC, IP, WB, ELISA
TDP-43	18280-1-AP	Rabbit Polyclonal	FC, IF, IHC, IP, WB, ELISA
Phospho-TDP43 (Ser409/410)	22309-1-AP	Rabbit Polyclonal	WB, ELISA
TDP-43 (human specific)	60019-2-Ig	Mouse Monoclonal	FC, IHC, IP, WB, ELISA
Phospho-TDP43 (Ser403/404)	66079-1-Ig	Mouse Monoclonal	FC, WB, ELISA
Phospho-TDP43 (Ser409/410)	66318-1-Ig	Mouse Monoclonal	WB, ELISA
TDP-43	66734-1-Ig	Mouse Monoclonal	FC, IHC, WB, ELISA
TDP-43 (C-terminal)	67345-1-Ig	Mouse Monoclonal	FC, IF, IHC, WB, ELISA
TDP-43	80001-1-RR	Rabbit Recombinant	FC, IHC, WB, ELISA
TDP-43 (for IF/FC)	80002-1-RR	Rabbit Recombinant	FC, IF, ELISA
Phospho-TDP43 (Ser409/410)	80007-1-RR	Rabbit Recombinant	IHC, WB, ELISA
TDP-43	CL488-10782	Rabbit Polyclonal	FC (Intra), IF
TDP-43 (C-terminal)	CL488-12892	Rabbit Polyclonal	FC (Intra), IF
TDP-43 (C-terminal)	CL488-67345	Mouse Monoclonal	IF
TDP-43 (for IF/FC)	CL488-80002	Rabbit Recombinant	FC (Intra), IF
TDP-43 (C-terminal)	CL594-12892	Rabbit Polyclonal	FC (Intra), IF
TDP-43 (C-terminal)	CL594-67345	Mouse Monoclonal	IF
TDP-43 (for IF/FC)	CL594-80002	Rabbit Recombinant	FC (Intra), IF
Human TDP-43 ELISA kit	KE00005	Mix	ELISA (plasma and serum)
Human TDP-43 ELISA kit	KE00009	Mix	ELISA (CSF and cell lysate)