Product Information
84516-6-PBS targets SAE1 in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | SAE1 fusion protein Ag0275 Predict reactive species |
Full Name | SUMO1 activating enzyme subunit 1 |
Calculated Molecular Weight | 38 kDa |
GenBank Accession Number | BC000344 |
Gene Symbol | SAE1 |
Gene ID (NCBI) | 10055 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q9UBE0 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
SAE1(SUMO-activating enzyme subunit 1) is also named as AOS1, SUA1, UBLE1A and belongs to the ubiquitin-activating E1 family. SAE1 has a calculated molecular mass of 38 kD. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins(PMID:9920803). Western blot analysis of synchronized HeLa cells detectes increased AOS1 expression as cells progressed through S phase, followed by a substantial decrease in G2 phase. Immunofluorescence analysis shows AOS1 and UBA2 distributed throughout nuclei, but they are excluded from nucleoli.(PMID:11481243).