Anticorps Polyclonal de lapin anti-RND3

• Phare
• Validé par KD/KO

RND3 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IP, IF, ELISA

Conjugaison

Non conjugué

Publications

6

N° de cat : 12534-1-AP

Synonymes

ARHE, memB, Protein MemB, Rho family GTPase 3, Rho8, RhoE, RND3

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Galerie de données de validation

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  IHC staining of human pancreas using 12534-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas slide using 12534-1-AP (RND3 Antibody) at dilution of 1:50.

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  IHC staining of human pancreas using 12534-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas slide using 12534-1-AP (RND3 Antibody) at dilution of 1:50.

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Applications testées

Applications publiées

• KD/KO: See 2 publications below
• WB: See 6 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Informations sur le produit

12534-1-AP cible RND3 dans les applications de WB, IP, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: rat, Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: RND3 Protéine recombinante Ag3235
• Nom complet: Rho family GTPase 3
• Masse moléculaire calculée: 244 aa, 27 kDa
• Numéro d’acquisition GenBank: BC012513
• Symbole du gène: RND3
• Identification du gène (NCBI): 390
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Rnd3, also known as RhoE, belongs to the Rnd subclass of the Rho family of small guanosine triphosphate (GTP)-binding proteins. Rnd proteins are unique due to their inability to switch from a GTP-bound to GDP-bound conformation. The basic role of Rnd3 is to report as an endogenous antagonist of RhoA signaling-mediated actin cytoskeleton dynamics, which specifically contributes to cell migration and neuron polarity. Rnd3 also plays a critical role in arresting cell cycle distribution, inhibiting cell growth, and inducing apoptosis and differentiation.

Publications

Species	Application	Title
human	WB,IP	Cancer Res; Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling.; Authors - Zehua Zhu
human	WB	J Mol Cell Biol; Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.; Authors - Zhou Yizhuo Y
RAT	WB,IF	J Am Heart Assoc; Rnd3 as a Novel Target to Ameliorate Microvascular Leakage.; Authors - Jerome W Breslin ; KD Validated
rat	WB	Life Sci; Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.; Authors - Cui Zhai
human	WB	Mol Cell Biochem; MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells.; Authors - Xia Wei W ; KD Validated
human	WB	Cancer Lett; KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells; Authors - Meihua Shan

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