Anticorps Polyclonal de lapin anti-FBXO32

• Phare
• Validé par KD/KO

FBXO32 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris et plus (3)

Applications

WB, IP, IHC, ELISA

Conjugaison

Non conjugué

Publications

19

N° de cat : 12866-1-AP

Synonymes

Atrogin 1, F box only protein 32, F box protein 32, Fbx32, FBXO32, MAFbx, Muscle atrophy F box protein

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Galerie de données de validation

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  WB analysis of mouse skeletal muscle using 12866-1-AP

  mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12866-1-AP (FBXO32 Antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse heart using 12866-1-AP

  mouse heart tissue were subjected to SDS PAGE followed by western blot with 12866-1-AP (FBXO32 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse skeletal muscle using 12866-1-AP

  mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12866-1-AP (FBXO32 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Applications testées

Applications publiées

• KD/KO: See 1 publications below
• WB: See 19 publications below
• IHC: See 1 publications below
• IP: See 1 publications below

Informations sur le produit

12866-1-AP cible FBXO32 dans les applications de WB, IP, IHC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: rat, Humain, poisson-zèbre, porc, souris, squirrel
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FBXO32 Protéine recombinante Ag3474
• Nom complet: F-box protein 32
• Masse moléculaire calculée: 355 aa, 42 kDa
• Numéro d’acquisition GenBank: BC024030
• Symbole du gène: FBXO32
• Identification du gène (NCBI): 114907
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

FBXO32 (F box only protein 32), also known as Atrogin 1 or MAFbx, is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif F-box. This protein is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. FBXO32 is thus a potential drug target for the treatment of muscle atrophy. Some data support that FBXO32 may play an important role in tumorigenesis. Recent study reveal that FBXO32 targets the oncogenic protein c-Myc for ubiquitination and degradation through the proteasome pathway.

Publications

Species	Application	Title
mouse	WB	J Cachexia Sarcopenia Muscle; Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.; Authors - Jie Dong
human	WB	Elife; The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy; Authors - Yurika Ito
mouse	WB	J Agric Food Chem; Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.; Authors - Luchu Zhang
mouse	WB	Aging (Albany NY); Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes.; Authors - Yehui Duan
mouse	WB,IHC	Oncotarget; PMID: 28489606; Authors - Dunwei Guo
zebrafish	WB	Nutrients; A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity.; Authors - Yun-Yi Zou

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