• Featured Product
  • KD/KO Validated

TRAF6 Polyklonaler Antikörper

TRAF6 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (2)

Anwendung

WB, IF, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12809-1-AP

Synonyme

RING finger protein 85, RNF85, TRAF6



Geprüfte Anwendungen

Produktinformation

12809-1-AP bindet in WB, IF, ELISA TRAF6 und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TRAF6 fusion protein Ag3555
Vollständiger Name TNF receptor-associated factor 6
Berechnetes Molekulargewicht 522 aa, 60 kDa
GenBank-ZugangsnummerBC031052
Gene symbol TRAF6
Gene ID (NCBI) 7189
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.

Publikationen

SpeciesApplicationTitle
humanWB, IF

Nat Immunol

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Authors - Jing Geng
humanWB

Autophagy

TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.

Authors - Tianyu Han
  • KD Validated
ratWB

Front Immunol

Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.

Authors - Hong Xiang
humanWB

Mol Cancer Res

TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells.

Authors - Fuping Wen
humanWB

Front Pharmacol

Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.

Authors - Hong Yao
ratWB

Eur J Immunol

Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO and PGE2 expression and inhibits NF- κB signaling in a mouse model of Alzheimer's disease.

Authors - Shi Shi