RND3 Polyklonaler Antikörper

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• KD/KO Validated

RND3 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IP, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

6

Kat-Nr. : 12534-1-AP

Synonyme

ARHE, memB, Protein MemB, Rho family GTPase 3, Rho8, RhoE, RND3

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Galerie der Validierungsdaten

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  IHC staining of human pancreas using 12534-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas slide using 12534-1-AP (RND3 Antibody) at dilution of 1:50.

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  IHC staining of human pancreas using 12534-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas slide using 12534-1-AP (RND3 Antibody) at dilution of 1:50.

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• KD/KO: See 2 publications below
• WB: See 6 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Produktinformation

12534-1-AP bindet in WB, IP, IF, ELISA RND3 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: RND3 fusion protein Ag3235
• Vollständiger Name: Rho family GTPase 3
• Berechnetes Molekulargewicht: 244 aa, 27 kDa
• GenBank-Zugangsnummer: BC012513
• Gene symbol: RND3
• Gene ID (NCBI): 390
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Rnd3, also known as RhoE, belongs to the Rnd subclass of the Rho family of small guanosine triphosphate (GTP)-binding proteins. Rnd proteins are unique due to their inability to switch from a GTP-bound to GDP-bound conformation. The basic role of Rnd3 is to report as an endogenous antagonist of RhoA signaling-mediated actin cytoskeleton dynamics, which specifically contributes to cell migration and neuron polarity. Rnd3 also plays a critical role in arresting cell cycle distribution, inhibiting cell growth, and inducing apoptosis and differentiation.

Publikationen

Species	Application	Title
human	WB,IP	Cancer Res; Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling.; Authors - Zehua Zhu
human	WB	J Mol Cell Biol; Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.; Authors - Zhou Yizhuo Y
RAT	WB,IF	J Am Heart Assoc; Rnd3 as a Novel Target to Ameliorate Microvascular Leakage.; Authors - Jerome W Breslin ; KD Validated
rat	WB	Life Sci; Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.; Authors - Cui Zhai
human	WB	Mol Cell Biochem; MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells.; Authors - Xia Wei W ; KD Validated
human	WB	Cancer Lett; KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells; Authors - Meihua Shan

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