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TFPI Monoclonal antibody, PBS Only

TFPI Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B12F11

Cat no : 66842-1-PBS

Synonyms

EPI, Extrinsic pathway inhibitor, LACI, TFI, TFPI, TFPI1

Validation Data Gallery

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  • Western Blot (WB) analysis of human placenta tissue using TFPI Monoclonal antibody (66842-1-Ig)

    WB analysis of human placenta using 66842-1-Ig (same clone as 66842-1-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 66842-1-Ig (TFPI antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66842-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HepG2 cells using TFPI Monoclonal antibody (66842-1-Ig)

    WB analysis of HepG2 using 66842-1-Ig (same clone as 66842-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 66842-1-Ig (TFPI antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66842-1-PBS in a different storage buffer formulation.

Product Information

66842-1-PBS targets TFPI in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen TFPI fusion protein Ag14980
Full Name tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Calculated Molecular Weight251aa,29 kDa; 304aa,35 kDa
Observed Molecular Weight 35-38 kDa
GenBank Accession NumberBC015514
Gene Symbol TFPI
Gene ID (NCBI) 7035
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Tissue factor pathway inhibitor (TFPI) is a critical anticoagulant protein present in endothelium and platelets. TFPI is produced as two major isoforms in humans, TFPIa and TFPIb that result from alternative splicing. The TFPIb isoform localizes to the endothelium surface where it is a potent inhibitor of tissue factor-factor VIIa complexes that initiate blood coagulation. The TFPIa isoform is present in platelets. TFPI is a Kunitz-type serine protease inhibitor that exerts anticoagulant activity by blocking early procoagulant stimulia. TFPI can enhance anti-thrombotic treatment in sepsis, inflammatory diseases, and cardiovascular diseases.