CoraLite® Plus 488-conjugated TACSTD2/TROP2 Monoclonal antibody

TACSTD2/TROP2 Monoclonal Antibody for IF/ICC

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

IF/ICC

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

5A6B1

Cat no : CL488-68141

Synonyms

TACSTD2, GA733-1, GA733 1, GA733, EGP 1



Tested Applications

Positive IF/ICC detected inHaCaT cells

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-68141 targets TACSTD2/TROP2 in IF/ICC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen TACSTD2/TROP2 fusion protein Ag25775
Full Name tumor-associated calcium signal transducer 2
Calculated Molecular Weight 36 kDa
Observed Molecular Weight40-50 kDa
GenBank Accession NumberBC009409
Gene Symbol TROP2
Gene ID (NCBI) 4070
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Trophoblast cell surface antigen 2 (TROP2), also named as TACSTD2, is a transmembrane glycoprotein. TROP2 plays a role in transducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. TROP2 is overexpressed in most carcinomas and is involved in cancer proliferation, migration, invasion, and metastasis. Congenital mutations of TROP2 cause a rare autosomal recessive disease which may lead to blindness-the gelatinous drop-like corneal disease (PMID: 35688908).

Protocols

Product Specific Protocols
IF protocol for CL Plus 488 TACSTD2/TROP2 antibody CL488-68141Download protocol
Standard Protocols
Click here to view our Standard Protocols