Product Information
84445-1-PBS targets SMURF2 in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | SMURF2 fusion protein Ag33419 Predict reactive species |
Full Name | SMAD specific E3 ubiquitin protein ligase 2 |
Calculated Molecular Weight | 748 aa, 86 kDa |
GenBank Accession Number | BC093876 |
Gene Symbol | SMURF2 |
Gene ID (NCBI) | 64750 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q9HAU4 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
SMURF2 is a HECT domain E3 ubiquitin ligase involved in degradation of SMADs,TGF-beta receptor,and other substrates.It also functions in regulation of neuronal and planar cell polarity, induction of senescence, and tumor suppression(PMID:22231558).SMURF2 associates constitutively with SMAD7 and it is nuclear, but binding to SMAD7 induces export and recruitment to activated TGFBR, where it causes degradation of receptors and of SMAD7 via proteasomal and lysosomal pathways(PMIF:11163210).