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PER1 Recombinant antibody, PBS Only

PER1 Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242096E3

Cat no : 84730-5-PBS

Synonyms

period homolog 1 (Drosophila), PER, KIAA0482, hPER1, hPER

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of NIH/3T3 cells using PER1 Recombinant antibody (84730-5-RR)

    IF Staining of NIH/3T3 using 84730-5-RR (same clone as 84730-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed NIH/3T3 cells using PER1 antibody (84730-5-RR, Clone: 242096E3 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84730-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84730-5-RR

    Affinity and Kinetic Characterization of 84730-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84730-5-RR against Human PER1 were performed. The affinity constant is 0.802 nM.

Product Information

84730-5-PBS targets PER1 in IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen PER1 fusion protein Ag4249
Full Name period homolog 1 (Drosophila)
Calculated Molecular Weight 1290 aa, 136 kDa
GenBank Accession NumberBC028207
Gene Symbol PER1
Gene ID (NCBI) 5187
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

PER1 is a master regulator of circadian rhythm and functions in the nucleus to repress expression of the central circadian clock genes. The periodicity of PER1 abundance, nuclear translocation, and transcriptional repression is regulated by PER1 phosphorylation, ubiquitination, and proteasomal degradation [PMID: 21514639]. It is one component of the circadian clock mechanism which is essential for generating circadian rhythms. It can influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus [PMID: 9856465, 20930143].