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NR1H4 Recombinant antibody, PBS Only

NR1H4 Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

4B4

Cat no : 81820-2-PBS

Synonyms

BAR, Bile acid receptor, Farnesoid X activated receptor, Farnesol receptor HRR 1, FXR, HRR 1, HRR1, NR1H4, RIP14, RXR interacting protein 14

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using NR1H4 Recombinant antibody (81820-2-RR)

    WB analysis using 81820-2-RR (same clone as 81820-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 81820-2-RR (NR1H4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 81820-2-PBS in a different storage buffer formulation.

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

81820-2-PBS targets NR1H4 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen NR1H4 fusion protein Ag21948
Full Name nuclear receptor subfamily 1, group H, member 4
Calculated Molecular Weight 486 aa, 56 kDa
Observed Molecular Weight 48 kDa
GenBank Accession NumberBC130573
Gene Symbol NR1H4
Gene ID (NCBI) 9971
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Nuclear Receptor subfamily 1, group H, member 4 (NR1H4, also known as FXR) is a receptor for bile acids and has an important role in regulating energy metabolism in liver, muscle and adipose tissues in humans and animals. NR1H4 is highly expressed in liver and has a role in lipid metabolism, whereas none of the other protein-coding genes in the region has known biological links with cholesterol, further supporting a role for NR1H4 in regulation of cholesterol levels. NR1H4 have four isoforms, i.e., FXRalpha1, FXRalpha2, FXRbeta1, and FXRbeta2, and each isoform has a different expressional level and transcriptional activity depending on its location within specific tissues. (PMID: 14733360, PMID: 30787420)