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CoraLite® Plus 488-conjugated MRP1 Monoclonal antibody

MRP1 Monoclonal Antibody for IF/ICC

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

IF/ICC

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1G4A2

Cat no : CL488-67228

Synonyms

ABCC1, 1G4A2

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of A549 cells using CoraLite® Plus 488-conjugated MRP1 Monoclonal anti (CL488-67228)

    IF Staining of A549 using CL488-67228

    Immunofluorescent analysis of (4% PFA) fixed A549 cells using CoraLite® Plus 488 MRP1 antibody (CL488-67228, Clone: 1G4A2 ) at dilution of 1:200.

Tested Applications

Positive IF/ICC detected inA549 cells

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-67228 targets MRP1 in IF/ICC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen MRP1 fusion protein Ag27048
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Calculated Molecular Weight 172 kDa
Observed Molecular Weight 180-190 kDa
GenBank Accession NumberNM_004996
Gene Symbol MRP1
Gene ID (NCBI) 4363
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Multidrug resistant-associated protein 1 (MRP1; ABCC1) is a member of the ATP-binding cassette (ABC) transporter protein superfamily, subfamily C. MRP1 is overexpressed in cancers and contributes to the occurrence of multidrug resistance (MDR). Expression of MRP1 has been considered as a negative marker for the outcome of chemotherapy. Recently MRP1 has been reported to play a crucial role in Aβ clearance at the blood-brain barrier.

Protocols

Product Specific Protocols
IF protocol for CL Plus 488 MRP1 antibody CL488-67228Download protocol
Standard Protocols
Click here to view our Standard Protocols