IGF2 Recombinant antibody, PBS Only

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  WB analysis of HuH-7 using 84643-1-RR (same clone as 84643-1-PBS)

  HuH-7 cells were subjected to SDS PAGE followed by western blot with 84643-1-RR (IGF2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84643-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84643-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84643-1-RR against Human IGF2 were performed. The affinity constant is 0.159 nM.

IGF2 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 84643-1-PBS

Clone No.241746D3

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

proIGF-II, PP1446, Insulin-like growth factor II Ala-25 Del, IGF-II, IGF II

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Product Information

84643-1-PBS targets IGF2 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: IGF2 fusion protein HZ-1161
• Full Name: insulin-like growth factor 2 (somatomedin A)
• Observed Molecular Weight: 20 kDa
• Gene Symbol: IGF2
• Gene ID (NCBI): 3481
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P01344
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Insulin-like growth factor 2 (IGF2) is a crucial protein that plays a significant role in regulating growth, particularly during normal fetal development, and is also often dysregulated during tumorigenesis. IGF2 is one of the main ligands of the type 1 IGF receptor (IGF-1R), a tyrosine kinase receptor that transmits signals upon binding with IGF-II. IGF2 is predominantly secreted via the placenta during pregnancy and, after birth, primarily by hepatocytes, with its secretion being independent of growth hormone (GH) secretion, unlike IGF-I.