• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human pro IGF-II protein

Activity(Primary)

12-80 ng/mL

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1161

Synonyms

C11orf43, FLJ22066, FLJ44734, IGF II, IGF2, INSIGF, Insulin like growth factor II, pp9974, Somatomedin A



Technical Specifications

GeneID 3481
Species Human
Expression HEK293
Activity(Primary) 12-80 ng/mL
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP01344
Molecular Mass 25 kDa reduced and non-reduced, monomer, glycosylated
Formulation 10 mM Tris-HCl pH 7.4 + 350 mM NaCl, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.

Background

IGF2 is a hormone involved in the regulation of cell proliferation, growth, migration, differentiation, and survival. IGF2 is mostly expressed in early embryonic and fetal development. Adult IGF2 expression occurs in the liver and epithelial cells lining the surface of the brain. IGF2 can also be detected in plasma (PMID: 24593700; 23257688)

Synonyms

C11orf43, FLJ22066, FLJ44734, IGF II, IGF2, INSIGF, Insulin like growth factor II, pp9974, Somatomedin A

Publications

SpeciesTitle
mouse

Stem Cells

Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration.

Authors - Madoka Ikemoto-Uezumi
human

J Clin Endocrinol Metab

Paracrine Pathways in Uterine Leiomyoma Stem Cells Involve Insulinlike Growth Factor 2 and Insulin Receptor A.

Authors - Molly B Moravek