Product Information
81984-2-PBS targets Histone H3 in WB, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Histone H3 fusion protein Ag10644 Predict reactive species |
Full Name | histone cluster 2, H3a |
Calculated Molecular Weight | 136 aa, 15 kDa |
Observed Molecular Weight | 15 kDa |
GenBank Accession Number | BC015544 |
Gene Symbol | Histone H3 |
Gene ID (NCBI) | 333932 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q71DI3 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Histone-H3, histone cluster 2, H3a is the core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone-H3 is expressed during S phase; then expression strongly decreases as cell division slows down during the process of differentiation.