Product Information
66849-1-PBS targets CPLX2 in WB, IHC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Reactivity | human, mouse, rat, pig |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | CPLX2 fusion protein Ag27949 Predict reactive species |
Full Name | complexin 2 |
Calculated Molecular Weight | 134 aa, 15 kDa |
Observed Molecular Weight | 18-20 kDa |
GenBank Accession Number | BC093706 |
Gene Symbol | CPLX2 |
Gene ID (NCBI) | 10814 |
RRID | AB_2882189 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q6PUV4 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Neuronal specific complexin 1 (CPLX1) has inhibitory and stimulatory effects on exocytosis by clamping trans-SNARE complexes in a prefusion state and promoting conformational changes to facilitate membrane fusion following cell stimulation. Complexin2 (CPLX2) is a pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals, it is downregulated in schizophrenic patients suffering from depression, animal models of depression and neurological disorders such as Huntington's disease in which depression is a major symptom.