Product Information
66221-1-PBS targets Alpha E-Catenin in Indirect ELISA, IHC, WB applications and shows reactivity with mouse, human samples.
Tested Reactivity | mouse, human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | Alpha E-Catenin fusion protein Ag23603 Predict reactive species |
Full Name | catenin (cadherin-associated protein), alpha 1, 102kDa |
Calculated Molecular Weight | 906 aa, 100 kDa |
Observed Molecular Weight | 95-100 kDa |
GenBank Accession Number | BC031262 |
Gene Symbol | Alpha E-Catenin |
Gene ID (NCBI) | 1495 |
RRID | AB_2881612 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P35221 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Alpha catenin is an essential component of adherens junctions that connects E-cadherin-β-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin, alpha-N-catenin, and alpha-T-catenin, which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed, alpha-N-catenin is restricted to neuronal tissue, and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers, including malignant tumours of the breast, colon, stomach, oesophagus, bladder and liver. In addition, the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis.