IL-6 Signaling : New Pathway poster

Download a pathway poster for your lab

All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.

---

IL-6 Signaling Overview

Interleukin-6 (IL-6) is an endogenous chemical with multiple forms and functions. It acts as both a pro and an anti-inflammatory cytokine (1). In the early phase of infectious inflammation, IL-6 is produced by monocytes and macrophages immediately after the stimulation of Toll-like receptors (TLRs) with distinct pathogen-associated molecular patterns (PAMPs). In non-infectious inflammation, such as a burn or traumatic injury, damage-associated molecular patterns (DAMPs) from damaged or dying cells stimulate TLRs to produce IL-6 (2).

IL-6 helps T-cells to differentiate in their development. It is required for progenitor cell development or helps B-cells differentiate and proliferate, and promotes the formation of plasma cells from B-cells. IL-6 also plays a vital role in the development of blood cells, whether white cells, red cells or platelets. Besides, IL-6 leads to the activation of osteoclasts and osteoporosis. It also induces the secretion of vascular endothelium growth factor (VEGF), which leads to the increased growth of blood vessels and vascular permeability in inflammation (3).

Genetic variations of IL6 are associated with rheumatoid arthritis systemic juvenile (RASJ), and its promoter polymorphism can be an indicator for Kaposi sarcoma development in HIV-infected men (4-5).

Download the IL-6 Pathway poster here

Related Antibodies

Antibody	Type	Catalog Number	Publications
IL-6 Antibody KD/KO Validated	Rabbit polyclonal	21865-1-AP	32
IL-6 Antibody	Mouse monoclonal	66146-1-Ig	2
AKT1 Antibody  KD/KO Validated	Rabbit Polyclonal	10176-2-AP	77
ERK1/2 Antibody	Mouse Monoclonal	66192-1-Ig	4
GRB2 Antibody KD/KO Validated	Rabbit Polyclonal	10254-2-AP	3
IKBKG Antibody KD/KO Validated	Rabbit Polyclonal	18474-1-AP	7
MTOR Antibody	Rabbit Polyclonal	20657-1-AP	20

Browse more pathway posters here

Request a printed poster

Select your chosen poster here:

AKT SignalingAlzheimer's DiseaseAML SignalingApoptosis PathwayBRCA PathwayCaspase Cascade PathwayER Stress PathwayGPCR PathwayGSK3 SignalingHedgehog SignalingIL-6 PathwayInsulin PathwayJAK/STAT SignalingJNK SignalingmTOR SignalingNeurotrophin PathwayNFKB PathwayNOTCH SignalingP53 SignalingRAS Receptor PathwayTGF-beta PathwayToll-like Receptor PathwayVEGF SignalingWnt SignalingAMPK PathwayATM PathwayBDNF PathwayeNOS PathwayEGF PathwayMAPK PathwayP38-MAPK Pathway

First Name *

Last Name *

Institution

Position

Full Delivery Address *

Zip / Postal code *

State

Email Address *

Do you use antibodies in your research regularly? *

Yes
No

Which category best describes your research area? *

CancerCardiovascularCell BiologyDevelopment BiologyEpigeneticsImmunologyMetabolismNeuroscienceSignal TransductionStem CellsOther

GDPR Agreement * I consent to having Proteintech store my submitted information so they can respond to my enquiry.

By completing this form you are agreeing to receive email communication from Proteintech. Personal data submitted will be processed in accordance with applicable data protection regulations and Proteintech’s privacy policy. You can unsubscribe at any time and update or remove personal data by contacting Proteintech.

References

1. The pro- and anti-inflammatory properties of the cytokine interleukin-6.
2. IL-6 as a keystone cytokine in health and disease.
3. The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis.
4. New insights in systemic juvenile idiopathic arthritis--from pathophysiology to treatment.
5. An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.