Anticorps Polyclonal de lapin anti-CD11B/Integrin Alpha M

CD11B/Integrin Alpha M Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF, IHC, ELISA

Conjugaison

Non conjugué

Publications

21

N° de cat : 20991-1-AP

Synonymes

CD11B, CR 3 alpha chain, CR3A, Integrin alpha M, ITGAM, MAC 1, MAC1A, MO1A, Neutrophil adherence receptor, SLEB6

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Galerie de données de validation

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  IHC staining of human liver using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human liver using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human tonsillitis using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human tonsillitis using 20991-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 20991-1-AP (CD11B/Integrin alpha M Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Applications testées

Applications publiées

• WB: See 15 publications below
• IHC: See 6 publications below
• IF: See 2 publications below

Informations sur le produit

20991-1-AP cible CD11B/Integrin Alpha M dans les applications de WB, IF, IHC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: integrin, alpha M (complement component 3 receptor 3 subunit)
• Masse moléculaire calculée: 93 kDa
• Poids moléculaire observé: 110-170 kDa
• Numéro d’acquisition GenBank: NM_000632
• Symbole du gène: CD11b
• Identification du gène (NCBI): 3684
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

Publications

Species	Application	Title
	IHC	J Nanobiotechnology; Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells; Authors - Hua‑Zhen Xu
human	IHC	Cancer Lett; Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.; Authors - Xiong Zhang
human	WB	Cancer Immunol Immunother; Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.; Authors - Pei Yang
	IF	J Nanobiotechnology; Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer.; Authors - Shen-Jun Yuan
	IHC	Neuropharmacology; Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide.; Authors - Liqing Zhang
	WB,IHC	Mol Neurobiol; Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration.; Authors - Weisong Duan

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