• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human OSM protein


0.1-1.5 ng/mL

Specific Activity

minimally 3.00 x 107 IU/mg

Species Reactivity




Cat no : HZ-1030


oncostatin M, OSM

Technical Specifications

GeneID 5008
Species Human
Expression HEK293
Activity(Primary) 0.1-1.5 ng/mL
Specific Activityminimally 3.00 x 107 IU/mg
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP13725
Molecular Mass 32 kDa reduced, 28 kDa non-reduced, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.


Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).


oncostatin M, OSM




CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia.

Authors - BorjaGuerra

Invest Ophthalmol Vis Sci

Role of Oncostatin M in the Pathogenesis of Vernal Keratoconjunctivitis: Focus on the Barrier Function of the Epithelium and Interleukin-33 Production by Fibroblasts

Authors - Ishin Ninomiya

Cancer Biomark

Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73.

Authors - HongyanLiang

Int J Dermatol

Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression

Authors - Delu Che

Skin Res Technol

Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis

Authors - Delu Che

Front Pharmacol

A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells.

Authors - Patricia Martín-Rodríguez


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


E (Verified Customer) (06-01-2022)

I used protein for hiPSC differentiation in hepatocyte cells and it works well

  • Applications: Cell culture
  • Cell Tissue Type: hiPSC

Toby (Verified Customer) (10-05-2021)

Recombinant Human OSM is used as part of our differentiation protocol, and is involved in the last stage in which we differentiate from a hepatoblast to a hepatocyte like cell. This product worked very well and aided with successful differentiation.

  • Applications: Cell culture,Other
  • Cell Tissue Type: Stem cell differentiation

Dongling (Verified Customer) (11-12-2018)

  • Applications: Flow Cytometry,Cell culture,Other,
  • Cell Tissue Type: iPSC's