- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human IL-7 protein
Activity(Primary)
0.1-1.4 ng/mL EC50
Specific Activity
>7.00x107 IU/mg
Species Reactivity
human,mouse
Purity
>95%
Cat no : HZ-1281
Synonyms
IL 7, IL7, IL-7, interleukin 7
Validation Data Gallery
Technical Specifications
GeneID | 3574 |
Species | Human |
Expression | HEK293 |
Activity(Primary) | 0.1-1.4 ng/mL EC50 |
Specific Activity | >7.00x107 IU/mg |
Purity | >95% |
Endotoxin | <1 EU/μg |
Accession Number | P10168 |
Molecular Mass | 19, 25, and 30 kDa, monomer, glycosylated |
Formulation | 1x PBS, See Certificate of Analysis for details |
Species Reactivity | human,mouse |
Stability and Reconstitution
Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
---|---|---|---|
Lyophilized | -20°C to -80°C | Until Expiry Date | |
Lyophilized | Room Temperature | 2 weeks | |
Reconstituted as per CofA | -20°C to -80°C | 6 months | |
Reconstituted as per CofA | 4°C | 1 week | |
Avoid repeated freeze-thaw cycles. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Background
Interleukin-7 (IL7) is a cytokine involved in B and T cell development. It plays an active role in the development, survival, maintaining and restoring homeostasis of mature T lymphocytes and is a key regulator of the commitment, survival, proliferation and maturation of B cells during development. Furthermore, IL7 can improve the antiviral function and expansion of natural killer (NK) cells and regulate the development and differentiation of dendritic cells. IL7 has also been reported as a regulator of the development of central nervous system and myogenesis and skeletal muscle cell migration (PMID: 29663382; 29655570; 29449560)
Synonyms
IL 7, IL7, IL-7, interleukin 7
Publications
Species | Title |
---|---|
Front Oncol Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells | |
Biochem J Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation | |
Heliyon Astragalus regulates the intestinal immune response during sepsis by mediating ILC3 proliferation through RORγt |