XPA Polyclonal antibody, PBS Only
XPA Polyclonal Antibody for WB, IF/ICC, FC (Intra), IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
WB, IF/ICC, FC (Intra), IP, Indirect ELISA
Conjugate
Unconjugated
Cat no : 16462-1-PBS
Synonyms
Validation Data Gallery
Product Information
16462-1-PBS targets XPA in WB, IF/ICC, FC (Intra), IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | XPA fusion protein Ag9536 |
Full Name | xeroderma pigmentosum, complementation group A |
Calculated Molecular Weight | 374aa,42 kDa; 273aa,31 kDa |
Observed Molecular Weight | 40 kDa |
GenBank Accession Number | BC014965 |
Gene Symbol | XPA |
Gene ID (NCBI) | 7507 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
XPA, also named as DNA repair protein complementing XP-A cells, is a 272 amino acid protein, which belongs to the XPA family. XPA is expressed in various cell lines and in skin fibroblasts. XPA is involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA is required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. The calculated molecular weight of XPA is 31 kDa, but modified XPA protein is about 40 kDa (PMID: 17848622).