- Featured Product
- KD/KO Validated
TMEM175 Monoclonal antibody, PBS Only
TMEM175 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat, pig, rabbit
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
1E7E1
Cat no : 68172-1-PBS
Synonyms
Validation Data Gallery
Product Information
68172-1-PBS targets TMEM175 in WB, ELISA applications and shows reactivity with human, mouse, rat, pig, rabbit samples.
Tested Reactivity | human, mouse, rat, pig, rabbit |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | TMEM175 fusion protein Ag13890 |
Full Name | transmembrane protein 175 |
Calculated Molecular Weight | 504 aa, 56 kDa |
Observed Molecular Weight | 55-60 kDa |
GenBank Accession Number | BC005158 |
Gene Symbol | TMEM175 |
Gene ID (NCBI) | 84286 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TMEM175 has two repeats of 6-transmembrane-spanning segments and has no GYG K+ channel sequence signature-containing, pore-forming P loop. Lysosomes lacking TMEM175 exhibit no K+conductance, have a markedly depolarized ΔΨ and little sensitivity to changes in [K+], and have compromised luminal pH stability and abnormal fusion with autophagosomes during autophagy. TMEM175 comprises a K+ channel that underlies the molecular mechanism of lysosomal K+ permeability.