Product Information
67022-1-PBS targets TIMELESS in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | TIMELESS fusion protein Ag6283 Predict reactive species |
Full Name | timeless homolog (Drosophila) |
Calculated Molecular Weight | 139 kDa |
Observed Molecular Weight | 140 kDa |
GenBank Accession Number | BC050557 |
Gene Symbol | TIMELESS |
Gene ID (NCBI) | 8914 |
RRID | AB_2882337 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q9UNS1 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TIMELESS1 (TIM1) gene encodes protein timeless homolog belonging to timeless family. TIM1 is localized in nucleus and regulated by cell cycle. It expresses high levels in S, G2 and M phases, and low in G0 and G1 phases. TIM1 is involved in the circadian rhythm autoregulatory loop and is a crucial component of the circadian core oscillator, which includes the CRY proteins, CLOCK, NPAS2, etc. It is also involved in cell survival after DNA damage or replication stress and reported to play important role in epithelial cell morphogenesis and formation of branching tubules.