CoraLite®594-conjugated SERPING1/C1 Inactivator Monoclonal antibody

SERPING1/C1 Inactivator Monoclonal Antibody for IF

Host / Isotype

Mouse / IgG2a

Reactivity

Human, pig, rat

Applications

IF/ICC

Conjugate

CoraLite®594 Fluorescent Dye

CloneNo.

1B11B11

Cat no : CL594-66882

Synonyms

C1 esterase inhibitor, C1 Inh, C1 inhibiting factor, C1IN, C1INH, C1NH, HAE1, HAE2, Plasma protease C1 inhibitor, Serpin G1, SERPING1

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Validation Data Gallery

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  IF Staining of HeLa using CL594-66882

  Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using CoraLite®594 SERPING1/C1 Inactivator antibody (CL594-66882, Clone: 1B11B11 ) at dilution of 1:200.

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Tested Applications

• Positive IF/ICC detected in: HeLa cells

Recommended dilution

• Immunofluorescence (IF)/ICC: IF/ICC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

CL594-66882 targets SERPING1/C1 Inactivator in IF/ICC applications and shows reactivity with Human, pig, rat samples.

• Tested Reactivity: Human, pig, rat
• Host / Isotype: Mouse / IgG2a
• Class: Monoclonal
• Type: Antibody
• Immunogen: SERPING1/C1 Inactivator fusion protein Ag16782
• Full Name: serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
• Calculated Molecular Weight: 500 aa, 55 kDa
• Observed Molecular Weight: 100 kDa
• GenBank Accession Number: BC011171
• Gene Symbol: SERPING1
• Gene ID (NCBI): 710
• Conjugate: CoraLite®594 Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 588 nm / 604 nm
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
• Storage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Background Information

SERPING1, also known as C1 Inhibitor (C1INH), is a member of the Serine proteinase inhibitor family. Its main function is the inhibition of the complement system to prevent spontaneous activation. It inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). C1INH is the most heavily glycosylated plasma protein.