SERPING1/C1 Inactivator Monoclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

SERPING1/C1 Inactivator Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, pig, rat

Applications

WB, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B11B11

Cat no : 66882-1-PBS

Synonyms

C1 esterase inhibitor, C1 Inh, C1 inhibiting factor, C1IN, C1INH, C1NH, HAE1, HAE2, Plasma protease C1 inhibitor, Serpin G1, SERPING1, SERPING1/C1 Inactivator

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Validation Data Gallery

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  WB analysis using 66882-1-Ig (same clone as 66882-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 66882-1-Ig (SERPING1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66882-1-PBS in a different storage buffer formulation.

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  IF Staining of HeLa using 66882-1-Ig (same clone as 66882-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using SERPING1/C1 Inactivator antibody (66882-1-Ig, Clone: 1B11B11 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 66882-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 66882-1-Ig (same clone as 66882-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using SERPING1/C1 Inactivator antibody (66882-1-Ig, Clone: 1B11B11 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66882-1-PBS in a different storage buffer formulation.

• 

  IF Staining of HepG2 using 66882-1-Ig (same clone as 66882-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using SERPING1/C1 Inactivator antibody (66882-1-Ig, Clone: 1B11B11 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66882-1-PBS in a different storage buffer formulation.

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Product Information

66882-1-PBS targets SERPING1/C1 Inactivator in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human, pig, rat samples.

• Tested Reactivity: Human, pig, rat
• Host / Isotype: Mouse / IgG2a
• Class: Monoclonal
• Type: Antibody
• Immunogen: SERPING1/C1 Inactivator fusion protein Ag16782
• Full Name: serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
• Calculated Molecular Weight: 500 aa, 55 kDa
• Observed Molecular Weight: 100 kDa
• GenBank Accession Number: BC011171
• Gene Symbol: SERPING1
• Gene ID (NCBI): 710
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

SERPING1, also known as C1 Inhibitor (C1INH), is a member of the Serine proteinase inhibitor family. Its main function is the inhibition of the complement system to prevent spontaneous activation. It inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). C1INH is the most heavily glycosylated plasma protein.