OGDHL Recombinant antibody, PBS Only
OGDHL Recombinant Antibody for IF, IHC, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
IF, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
230228B2
Cat no : 82981-1-PBS
Synonyms
Validation Data Gallery
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
82981-1-PBS targets OGDHL in IF, IHC, Indirect ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | OGDHL fusion protein Ag10794 |
Full Name | oxoglutarate dehydrogenase-like |
Calculated Molecular Weight | 1010 aa, 115 kDa |
GenBank Accession Number | BC026320 |
Gene Symbol | OGDHL |
Gene ID (NCBI) | 55753 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
OGDHL(oxoglutarate dehydrogenase-like) is also named as KGDE1KL, FLJ10851, KIAA1290 and belongs to the alpha-ketoglutarate dehydrogenase family. OGDHL is one of the rate-limiting component of the multienzyme OGDH complex (OGDHC) whose malfunction is associated with neuro-degeneration and it is localized only in the mitochondrial fraction and not in the cytosolic or nuclear fractions(PMID:23152800). OGDHL negatively regulates cell proliferation by inducing apoptosis in cervical cancer cells. It may thus participate in brain-specific control of 2-oxoglutarate distribution between energy production and synthesis of the neurotransmitter glutamate(PMID:18783430). It has 3 isoforms(114 kDa, 108 kDa, 91 kDa) produced by alternative splicing.