NeutraKine®M-CSF Monoclonal antibody

NeutraKine®M-CSF Monoclonal Antibody for ELISA, Neutralization
Cat No. 69033-1-Ig
Clone No.4C6C5

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

ELISA, Neutralization

CSF 1, CSF1, Lanimostim, M CSF, MCSF, M-CSF, NeutraKine®M-CSF

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


NeutralizationOCI-AML5 cells

Product Information

69033-1-Ig targets NeutraKine®M-CSF in ELISA, Neutralization applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Affinity
KD=8.48 x 10-9M
KOff=4.75 x 10-4M
KOn=5.60 x 104M
Immunogen human HumankineM-CSF protein HZ-1192 Predict reactive species
Full Name colony stimulating factor 1 (macrophage)
Gene Symbol M-CSF
Gene ID (NCBI) 1435
RRIDAB_3085334
Conjugate Unconjugated
Form Lyophilized Powder
Purification MethodProtein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

M-CSF plays an essential role in the regulation of survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. M-CSF promotes the release of proinflammatory chemokines and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. On the cellular level, M-CSF promotes reorganization of the actin cytoskeleton, regulates the formation of membrane ruffles, cell adhesion, and cell migration, and plays a role in lipoprotein clearance.

This antibody is used to neutralize the bioactivity of M-CSF.

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