MYB/c-Myb Polyclonal antibody, PBS Only
MYB/c-Myb Polyclonal Antibody for WB, IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IP, Indirect ELISA
Conjugate
Unconjugated
Cat no : 17800-1-PBS
Synonyms
Validation Data Gallery
Product Information
17800-1-PBS targets MYB/c-Myb in WB, IP, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | MYB/c-Myb fusion protein Ag12021 |
Full Name | v-myb myeloblastosis viral oncogene homolog (avian) |
Calculated Molecular Weight | 640 aa, 72 kDa |
Observed Molecular Weight | 40-50 kDa, 72-80 kDa |
GenBank Accession Number | BC064955 |
Gene Symbol | c-Myb |
Gene ID (NCBI) | 4602 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The MYB protein is a transcription factor that plays a key role in regulating the proliferation/differentiation of progenitor cells in bone marrow, colonic crypts, and neurogenic niches [PMID:18574464]. It is involved in the regulation of epithelial-to-mesenchymal transition (EMT) and invasion in neuroblastoma, colon carcinoma, and embryonic kidney cells through the upregulation of the transcription repressor Slug [PMID:20622260]. It also a DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3', and plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. MYB exists some isoforms with MV 85, 75, 72, 68, 63 and 40 kDa.