CoraLite® Plus 488-conjugated MAFB Polyclonal antibody

MAFB Polyclonal Antibody for

Host / Isotype

Rabbit / IgG

Reactivity

human, rat, mouse

Applications

Conjugate

CoraLite® Plus 488 Fluorescent Dye

Cat no : CL488-20189

Synonyms

KRML, Maf B, MAFB, Transcription factor MafB

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Validation Data Gallery

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Recommended dilution

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-20189 targets MAFB in applications and shows reactivity with human, rat, mouse samples.

• Tested Reactivity: human, rat, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: MAFB fusion protein Ag14102
• Full Name: v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
• Calculated Molecular Weight: 323 aa, 36 kDa
• Observed Molecular Weight: 45 kDa
• GenBank Accession Number: BC036689
• Gene Symbol: MAFB
• Gene ID (NCBI): 9935
• Conjugate: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 493 nm / 522 nm
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
• Storage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Background Information

MAFB (MAF BZIP Transcription Factor B), also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, is a widely expressed basic leucine zipper transcription factor belonging to the Maf family. MAFB expression is significantly elevated in response to a broad range of metabolic and immunological stimuli that promote macrophage M2 polarization, cholesterol efflux, or both, whereas it is strongly down-regulated in response to various pro-inflammatory pathogenic triggers(PMID: 28790455). MAFB is highly expressed in tumor tissues and required for proliferation and tumorigenicity of osteosarcoma cells(PMID: 32234710) and is a marker of tumor-associated macrophages in both mouse and human(PMID: 31679694).