CoraLite® Plus 750 Anti-Human LRP1 (5A6)
LRP1 Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG2b
Reactivity
Human
Applications
FC
Conjugate
CoraLite® Plus 750 Fluorescent Dye
CloneNo.
5A6
Cat no : CL750-65233
Synonyms
Validation Data Gallery
Tested Applications
Positive FC detected in | U-87 MG cells |
Recommended dilution
Application | Dilution |
---|---|
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
CL750-65233 targets LRP1 in FC applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | Full length native protein (purified) |
Full Name | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) |
Calculated Molecular Weight | 505 kDa |
GenBank Accession Number | BC045107 |
Gene Symbol | LRP1 |
Gene ID (NCBI) | 4035 |
Conjugate | CoraLite® Plus 750 Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 755 nm / 780 nm |
Form | Liquid |
Purification Method | Affinity purification |
Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA. |
Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Background Information
LRP1 (Prolow-density lipoprotein receptor-related protein 1), also known as A2MR, APOER and CD91, is a type I transmembrane protein that belongs to the LDLR family. LRP1 is synthesized as a transmembrane glycosylated precursor of 600 kDa, and is subsequently cleaved to generate a large 515-kDa N-terminal extracellular subunit and an 85-kDa C-terminal transmembrane subunit, which are noncovalently associated with one another (PMID: 2112085; 8546712). LRP1 is a multifunctional receptor involved in the clearance of a large number of diverse ligands and modulating various cellular processes. LRP1 is implicated in conditions such as atherosclerosis, cancer and neurodegenerative diseases (PMID: 28381441).
Protocols
Product Specific Protocols | |
---|---|
FC protocol for CL Plus 750 LRP1 antibody CL750-65233 | Download protocol |
Standard Protocols | |
---|---|
Click here to view our Standard Protocols |