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Integrin alpha-5 Recombinant antibody, PBS Only

Integrin alpha-5 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241684E8

Cat no : 84468-5-PBS

Synonyms

ITGA5, Integrin alpha-5 light chain, Integrin alpha-5 heavy chain, FNRA, CD49e

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Integrin alpha-5 Recombinant antibody (84468-5-RR)

    WB analysis using 84468-5-RR (same clone as 84468-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84468-5-RR (Integrin alpha-5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84468-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84468-5-RR

    Affinity and Kinetic Characterization of 84468-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84468-5-RR against Human Integrin alpha-5 were performed. The affinity constant is 1.41 nM.

Product Information

84468-5-PBS targets Integrin alpha-5 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant Protein
Full Name integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Calculated Molecular Weight 115 kDa
Observed Molecular Weight140 kDa
GenBank Accession NumberBC008786
Gene Symbol Integrin alpha 5
Gene ID (NCBI) 3678
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin alpha 5 (ITGA5), belongs to the integrin alpha chain family, primarily binds to Integrin beta 1 (ITGB1) to form an α5β1 heterodimer (PMID: 33711961). Integrin α5β1 is a specific receptor of fibronectin through its arginine-glycine-aspartic acid (RGD) binding site (PMID: 19608542). Integrin α5β1 plays roles in cell adhesion, migration and matrix formation, and has emerged as an essential mediator in many human carcinomas (PMID: 33408483).