Anti-Human IL-10RB Rabbit Recombinant Antibody, PBS Only

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  FC experiment of human PBMCs using 98292-1-RR (same clone as 98292-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-10RB Rabbit RecAb (98292-1-RR, Clone: 242302D2) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human HLA-DR (L243) Mouse IgG2a Recombinant Antibody (CL647-65560, Clone: L243). Cells were not fixed. This data was developed using the same antibody clone with 98292-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98292-1-RR (same clone as 98292-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-10RB Rabbit RecAb (98292-1-RR, Clone:242302D2) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98292-1-PBS in a different storage buffer formulation.

IL-10RB {ptg:Brand} Recombinant Antibody for FC

Cat No. 98292-1-PBS

Clone No.242302D2

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

IL10RB, Cytokine receptor class-II member 4, CRFB4, CRF2-4, CRF2 4

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Product Information

98292-1-PBS targets IL-10RB in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: interleukin 10 receptor, beta
• Calculated Molecular Weight: 37 kDa
• GenBank Accession Number: BC001903
• Gene Symbol: IL10RB
• Gene ID (NCBI): 3588
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q08334
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in maintaining immune system balance. IL-10 signals through a receptor complex consisting of two molecules of the IL-10R alpha-chain (IL-10RA) and two molecules of the accessory IL-10R beta-chain (IL-10RB) (PMID: 22236434). IL-10RA and IL-10RB are members of the type II cytokine receptor family. IL-10RB, also known as IL-10R2 or CDw210b, is the signaling subunit of the IL-10R complex and is constitutively expressed in a variety of cell types (PMID: 24507158). Binding of IL-10 to the IL-10R complex leads to JAK1- and TYK2-mediated phosphorylation of STAT3 (PMID: 11244051; 10433356). IL-10RB is also shared by several other cytokines, including IL22, IL-26, IFN-γ, IL-28A/B and IL29 (PMID: 22236434).