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  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human IL-10RB Rabbit Recombinant Antibody (98292-1-RR)

    FC experiment of human PBMCs using 98292-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-10RB Rabbit RecAb (98292-1-RR, Clone: 242302D2) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human HLA-DR (L243) Mouse IgG2a Recombinant Antibody (CL647-65560, Clone: L243). Cells were not fixed.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human IL-10RB Rabbit Recombinant Antibody (98292-1-RR)

    FC experiment of human PBMCs using 98292-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-10RB Rabbit RecAb (98292-1-RR, Clone:242302D2) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

Anti-Human IL-10RB Rabbit Recombinant Antibody

IL-10RB {ptg:Brand} Recombinant Antibody for FC
Cat No. 98292-1-RR
Clone No.242302D2

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

IL10RB, Cytokine receptor class-II member 4, CRFB4, CRF2-4, CRF2 4

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

- +

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Tested Applications

Positive FC detected inhuman PBMCs

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98292-1-RR targets IL-10RB in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein Predict reactive species
Full Name interleukin 10 receptor, beta
Calculated Molecular Weight 37 kDa
GenBank Accession NumberBC001903
Gene Symbol IL10RB
Gene ID (NCBI) 3588
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ08334
Storage Buffer PBS with 0.09% sodium azide , pH 7.3
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

Background Information

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in maintaining immune system balance. IL-10 signals through a receptor complex consisting of two molecules of the IL-10R alpha-chain (IL-10RA) and two molecules of the accessory IL-10R beta-chain (IL-10RB) (PMID: 22236434). IL-10RA and IL-10RB are members of the type II cytokine receptor family. IL-10RB, also known as IL-10R2 or CDw210b, is the signaling subunit of the IL-10R complex and is constitutively expressed in a variety of cell types (PMID: 24507158). Binding of IL-10 to the IL-10R complex leads to JAK1- and TYK2-mediated phosphorylation of STAT3 (PMID: 11244051; 10433356). IL-10RB is also shared by several other cytokines, including IL22, IL-26, IFN-γ, IL-28A/B and IL29 (PMID: 22236434).

Protocols

Product Specific Protocols
FC protocol for IL-10RB antibody 98292-1-RRDownload protocol
Standard Protocols
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