Product Information
83751-6-PBS targets GBP1 in WB, FC (Intra), ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | GBP1 fusion protein Ag7562 Predict reactive species |
| Full Name | GTP binding protein 1 |
| Calculated Molecular Weight | 68 kDa |
| Observed Molecular Weight | 67 kDa |
| GenBank Accession Number | BC002666 |
| Gene Symbol | GBP1 |
| Gene ID (NCBI) | 2633 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | P32455 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Guanylate binding protein 1 (GBP1) belongs to the dynamin superfamily of large GTPases. The expression of GBP1 is induced by interferon and GBP1 is characterized by its ability to specifically bind guanine nucleotides such as GMP, GDP, and GTP and its ability to hydrolyze GTP to GDP and GMP. GBP1 is induced in response to type I and type II interferons and as such plays a role in protective immunity against a spectrum of intracellular pathogens ranging from viruses to bacteria to protozoa, such as negative-strand RNA Rhabdovirus, vesicular stomatitis virus, and the positive-strand RNA Picornovirus, encephalomyocarditis virus in cultured cells, the inhibition of Chlamydia trachomatis, Toxoplasma gondii, and Salmonella enterica.
