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G6PC Polyclonal antibody, PBS Only

G6PC Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 29084-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using G6PC Polyclonal antibody (29084-1-AP)

    WB analysis using 29084-1-AP (same clone as 29084-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29084-1-AP (G6PC antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29084-1-PBS in a different storage buffer formulation.

Product Information

29084-1-PBS targets G6PC in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen G6PC fusion protein Ag30614
Full Name glucose-6-phosphatase, catalytic subunit
Calculated Molecular Weight 357 aa, 40 kDa
Observed Molecular Weight 40 kDa
GenBank Accession NumberBC130478
Gene Symbol G6PC
Gene ID (NCBI) 2538
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Glucose-6-phosphatase-α (G6PC) is a key enzyme in glucose homeostasis that catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the terminal step of gluconeogenesis and glycogenolysis. G6PC activity is restricted to the liver , the kidney cortex and the small intestine and confers on these three organs the capacity to release glucose into the systemic circulation (PMID: 21983240).The encoded enzyme is anchored to the ER by nine transmembrane helices with the amino (N)-terminus in the lumen and the carboxyl (C)-terminus in the cytoplasm (PMID: 15542400).